SB 203580 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种特异性 p38 MAPK 抑制剂，IC50 为 0.6 uM。

A specific p38 MAPK inhibitor with IC50 of 0.6 uM; shows selectivity over JNK, p42 MAPK, p90 S6K, p70 S6K, PKA, etc.; suppresses the activation of MAPKAP kinase-2 and prevents the phosphorylation of HSP27 in response to interleukin-1, cellular stresses and bacterial endotoxin in vivo.

Cell Proliferation Assay Cell Line:CT6, BA/F3 cell line F7, and PBMC/T cells Concentration:0-30 μM Incubation Time:Preincubated with 0-30 μM SB203580 for 1 h and cultured for 24 h in the presence of 20 ng/mL IL-2 Result:Prevented the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3-5 μM.Western Blot Analysis Cell Line:CT6 cells, activated human T cells, and BA/F3 F7 cells Concentration:0-30 μM Incubation Time:Preincubated with 0-30 μM SB203580 for 1 h before stimulating with 20 ng/mL IL-2 for 5 min Result:Inhibited the phosphorylation of PKB at Ser473 in a dose-dependent manner.

Animal Model:Six-week-old female atymic Nu/Nu mice CAL27 p38WT and p38TM tumors Dosage:5 mg/kg/day Administration:Intra peritoneal injected daily for 16 consecutive days Result:After 2 weeks treatment, CAL27 p38WT tumors were significantly smaller; CAL27 p38TM tumors were not affected by the p38 inhibitor (n=10). ?

RWJ 64809 hydrochloride | SB203580 hydrochloride | SB-203580 hydrochloride

MAPK/ERK Signaling

p38 MAPK

p38 MAPK

Cancer

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869185-85-3

413.8956

C21H17ClFN3OS

>98% (HPLC)

H2O: 8.43 mg/mL

O=S(C)C(C=C1)=CC=C1C(N2)=NC(C3=CC=NC=C3)=C2C4=CC=C(F)C=C4.Cl

Pyridine, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-, hydrochloride (1:1)

(-20℃)

With Ice Pack

≥ 2 years